# RO4929097 and Whole-Brain Radiation Therapy or Stereotactic Radiosurgery in Treating Patients With Brain Metastases From Breast Cancer

> **NCT01217411** · PHASE1,PHASE2 · TERMINATED · sponsor: **National Cancer Institute (NCI)** · enrollment: 5 (actual)

## Conditions studied

- Adult Solid Neoplasm
- Extensive Stage Lung Small Cell Carcinoma
- HER2/Neu Negative
- HER2/Neu Positive
- Male Breast Carcinoma
- Metastatic Malignant Neoplasm in the Brain
- Recurrent Breast Carcinoma
- Recurrent Lung Non-Small Cell Carcinoma
- Recurrent Lung Small Cell Carcinoma
- Recurrent Melanoma
- Stage IV Breast Cancer AJCC v6 and v7
- Stage IV Cutaneous Melanoma AJCC v6 and v7
- Stage IV Lung Non-Small Cell Cancer AJCC v7

## Interventions

- **PROCEDURE:** Cognitive Assessment
- **DRUG:** Gamma-Secretase Inhibitor RO4929097
- **OTHER:** Laboratory Biomarker Analysis
- **RADIATION:** Stereotactic Radiosurgery
- **RADIATION:** Whole-Brain Radiotherapy

## Key facts

- **NCT ID:** NCT01217411
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2010-10-01
- **Primary completion:** 2011-11-30
- **Final completion:** 2011-11-30
- **Target enrollment:** 5 (ACTUAL)
- **Why stopped:** Other - Protocol moved to Administratively Complete
- **Last updated:** 2024-11-19


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01217411

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01217411, "RO4929097 and Whole-Brain Radiation Therapy or Stereotactic Radiosurgery in Treating Patients With Brain Metastases From Breast Cancer". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT01217411. Licensed CC0.

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