# Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant

> **NCT01231412** · PHASE3 · COMPLETED · sponsor: **Fred Hutchinson Cancer Center** · enrollment: 174 (actual)

## Conditions studied

- Acute Lymphoblastic Leukemia
- Acute Myeloid Leukemia
- Aggressive Non-Hodgkin Lymphoma
- Chronic Lymphocytic Leukemia
- Diffuse Large B-Cell Lymphoma
- Hematopoietic and Lymphoid Cell Neoplasm
- Indolent Non-Hodgkin Lymphoma
- Mantle Cell Lymphoma
- Myelodysplastic Syndrome
- Myeloproliferative Neoplasm
- Prolymphocytic Leukemia
- Recurrent Chronic Lymphocytic Leukemia
- Recurrent Plasma Cell Myeloma
- Refractory Chronic Lymphocytic Leukemia
- Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Refractory Hodgkin Lymphoma
- Small Lymphocytic Lymphoma
- T-Cell Chronic Lymphocytic Leukemia
- Waldenstrom Macroglobulinemia

## Interventions

- **PROCEDURE:** Allogeneic Hematopoietic Stem Cell Transplantation
- **DRUG:** Cyclosporine
- **DRUG:** Fludarabine Phosphate
- **DRUG:** Mycophenolate Mofetil
- **PROCEDURE:** Peripheral Blood Stem Cell Transplantation
- **DRUG:** Sirolimus
- **RADIATION:** Total-Body Irradiation

## Key facts

- **NCT ID:** NCT01231412
- **Lead sponsor:** Fred Hutchinson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2010-11
- **Primary completion:** 2016-10-08
- **Final completion:** 2017-06-30
- **Target enrollment:** 174 (ACTUAL)
- **Last updated:** 2026-04-30

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01231412

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01231412, "Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT01231412. Licensed CC0.

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