# Sirolimus, Cyclosporine, and Mycophenolate Mofetil in Preventing Graft-versus-Host Disease in Treating Patients With Blood Cancer Undergoing Donor Peripheral Blood Stem Cell Transplant

> **NCT01251575** · PHASE2 · COMPLETED · sponsor: **Fred Hutchinson Cancer Center** · enrollment: 77 (actual)

## Conditions studied

- Adult Acute Lymphoblastic Leukemia
- Adult Acute Myeloid Leukemia
- Adult Diffuse Large B-Cell Lymphoma
- Adult Myelodysplastic Syndrome
- Adult Non-Hodgkin Lymphoma
- Aggressive Non-Hodgkin Lymphoma
- Childhood Acute Lymphoblastic Leukemia
- Childhood Acute Myeloid Leukemia
- Childhood Diffuse Large B-Cell Lymphoma
- Childhood Myelodysplastic Syndrome
- Childhood Non-Hodgkin Lymphoma
- Chronic Lymphocytic Leukemia
- Chronic Lymphocytic Leukemia in Remission
- Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Hematopoietic and Lymphoid Cell Neoplasm
- Mantle Cell Lymphoma
- Plasma Cell Myeloma
- Prolymphocytic Leukemia
- Recurrent Chronic Lymphocytic Leukemia
- Refractory Chronic Lymphocytic Leukemia
- T-Cell Prolymphocytic Leukemia
- Waldenstrom Macroglobulinemia
- Recurrent Diffuse Large B-Cell Lymphoma
- Recurrent Hodgkin Lymphoma

## Interventions

- **PROCEDURE:** Allogeneic Hematopoietic Stem Cell Transplantation
- **DRUG:** Cyclosporine
- **DRUG:** Fludarabine Phosphate
- **OTHER:** Laboratory Biomarker Analysis
- **DRUG:** Mycophenolate Mofetil
- **PROCEDURE:** Peripheral Blood Stem Cell Transplantation
- **DRUG:** Sirolimus
- **RADIATION:** Total-Body Irradiation

## Key facts

- **NCT ID:** NCT01251575
- **Lead sponsor:** Fred Hutchinson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2010-12-01
- **Primary completion:** 2018-11-23
- **Final completion:** 2019-02-11
- **Target enrollment:** 77 (ACTUAL)
- **Last updated:** 2019-12-09

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01251575

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01251575, "Sirolimus, Cyclosporine, and Mycophenolate Mofetil in Preventing Graft-versus-Host Disease in Treating Patients With Blood Cancer Undergoing Donor Peripheral Blood Stem Cell Transplant". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT01251575. Licensed CC0.

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