Dasatinib Followed by Stem Cell Transplant in Treating Older Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

NCT01256398 · clinicaltrials.gov ↗

PHASE2

Phase

COMPLETED

Status

66

Enrollment

NIH

Sponsor class

Conditions

Acute Lymphoblastic Leukemia
Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1

Interventions

BIOLOGICAL: Alemtuzumab
PROCEDURE: Allogeneic Hematopoietic Stem Cell Transplantation
PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation
DRUG: Cyclophosphamide
DRUG: Cytarabine
DRUG: Dasatinib
DRUG: Daunorubicin Hydrochloride
DRUG: Dexamethasone
DRUG: Etoposide Phosphate
BIOLOGICAL: Filgrastim
DRUG: Fludarabine Phosphate
PROCEDURE: In Vitro-Treated Peripheral Blood Stem Cell Transplantation
OTHER: Laboratory Biomarker Analysis
DRUG: Leucovorin Calcium
DRUG: Melphalan
DRUG: Mercaptopurine
DRUG: Methotrexate
BIOLOGICAL: Pegfilgrastim
OTHER: Pharmacological Study
DRUG: Tacrolimus

Sponsor

National Cancer Institute (NCI)