RO4929097 in Treating Patients With Recurrent Invasive Gliomas

NCT01269411 · clinicaltrials.gov ↗

PHASE1

Phase

TERMINATED

Status

22

Enrollment

NIH

Sponsor class

Stopped Administratively complete.

Conditions

Adult Anaplastic Oligodendroglioma
Adult Brain Stem Glioma
Adult Giant Cell Glioblastoma
Adult Glioblastoma
Adult Gliosarcoma
Adult Mixed Glioma
Recurrent Adult Brain Tumor

Interventions

DRUG: gamma-secretase/Notch signalling pathway inhibitor RO4929097
PROCEDURE: therapeutic conventional surgery
OTHER: pharmacological study
OTHER: laboratory biomarker analysis

Sponsor

National Cancer Institute (NCI)