# The Effect of Problem Solving Therapy and Antidepressant Therapy on Cerebral Perfusion and Brain Derived Neurotropic Factor (BDNF) in Depressed Elders

> **NCT01305889** · NA · COMPLETED · sponsor: **University of California, San Francisco** · enrollment: 19 (actual)

## Conditions studied

- Major Depressive Disorder

## Interventions

- **BEHAVIORAL:** problem solving therapy
- **DRUG:** Sertraline

## Key facts

- **NCT ID:** NCT01305889
- **Lead sponsor:** University of California, San Francisco
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2011-03
- **Primary completion:** 2018-02-16
- **Final completion:** 2018-02-16
- **Target enrollment:** 19 (ACTUAL)
- **Last updated:** 2022-05-26

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01305889

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01305889, "The Effect of Problem Solving Therapy and Antidepressant Therapy on Cerebral Perfusion and Brain Derived Neurotropic Factor (BDNF) in Depressed Elders". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT01305889. Licensed CC0.

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