# Caspofungin Versus Fluconazole in Preventing Invasive Fungal Infections (IFI) in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia

> **NCT01307579** · PHASE3 · COMPLETED · sponsor: **Children's Oncology Group** · enrollment: 517 (actual)

## Conditions studied

- Acute Myeloid Leukemia
- Adult Acute Monoblastic Leukemia
- Adult Acute Monocytic Leukemia
- Adult Acute Myeloid Leukemia in Remission
- Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11
- Adult Acute Myeloid Leukemia With Maturation
- Adult Acute Myeloid Leukemia With Minimal Differentiation
- Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11
- Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1
- Adult Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A
- Adult Acute Myeloid Leukemia Without Maturation
- Adult Acute Myelomonocytic Leukemia
- Alkylating Agent-Related Acute Myeloid Leukemia
- Childhood Acute Monoblastic Leukemia
- Childhood Acute Monocytic Leukemia
- Childhood Acute Myeloid Leukemia in Remission
- Childhood Acute Myeloid Leukemia With Maturation
- Childhood Acute Myeloid Leukemia With Minimal Differentiation
- Childhood Acute Myeloid Leukemia Without Maturation
- Childhood Acute Myelomonocytic Leukemia
- Fungal Infection
- Myeloid Neoplasm
- Neutropenia
- Recurrent Adult Acute Myeloid Leukemia
- Recurrent Childhood Acute Myeloid Leukemia
- Secondary Acute Myeloid Leukemia
- Untreated Adult Acute Myeloid Leukemia
- Untreated Childhood Myeloid Neoplasm

## Interventions

- **DRUG:** Caspofungin Acetate
- **DRUG:** Fluconazole
- **OTHER:** Laboratory Biomarker Analysis

## Key facts

- **NCT ID:** NCT01307579
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2011-04-04
- **Primary completion:** 2018-06-30
- **Final completion:** 2020-06-30
- **Target enrollment:** 517 (ACTUAL)
- **Last updated:** 2021-03-30

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01307579

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01307579, "Caspofungin Versus Fluconazole in Preventing Invasive Fungal Infections (IFI) in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT01307579. Licensed CC0.

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