# Bone Marrow Transplant Using a Reduced Intensity Regimen That is Given in Two Steps

> **NCT01350258** · PHASE1,PHASE2 · TERMINATED · sponsor: **Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University** · enrollment: 8 (actual)

## Conditions studied

- Hematologic Malignancies
- Acute Leukemia
- Myelodysplastic Syndromes (MDS) Other Than RA or RARS Subtypes
- Hodgkin's Lymphoma
- Non-Hodgkin's Lymphoma
- Myeloma
- Chronic Myelogenous (or Myeloid) Leukemia (CML) Resistant to STI Therapy

## Interventions

- **DRUG:** Fludarabine
- **DRUG:** Thiotepa
- **RADIATION:** Total Body Irradiation (TBI)
- **BIOLOGICAL:** Donor Lymphocyte Infusion (DLI)
- **DRUG:** Melphalan
- **DEVICE:** Hematopoietic stem cell transplantation (HSCT)

## Key facts

- **NCT ID:** NCT01350258
- **Lead sponsor:** Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2011-04
- **Primary completion:** 2012-05
- **Final completion:** 2012-08
- **Target enrollment:** 8 (ACTUAL)
- **Why stopped:** Poor accrual
- **Last updated:** 2025-05-31


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01350258

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01350258, "Bone Marrow Transplant Using a Reduced Intensity Regimen That is Given in Two Steps". Retrieved via AI Analytics 2026-06-10 from https://api.ai-analytics.org/clinical/NCT01350258. Licensed CC0.

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