Olaparib and Temozolomide in Treating Patients With Relapsed Glioblastoma

Conditions

• Brain and Central Nervous System Tumors

Interventions

• DRUG: olaparib
• DRUG: temozolomide
• GENETIC: gene expression analysis
• GENETIC: protein expression analysis
• OTHER: laboratory biomarker analysis
• OTHER: pharmacological study
• PROCEDURE: diffusion-weighted magnetic resonance imaging
• PROCEDURE: dynamic contrast-enhanced magnetic resonance imaging
• PROCEDURE: therapeutic conventional surgery

Sponsor

Cancer Research UK