# Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone

> **NCT01594047** · NA · COMPLETED · sponsor: **Fondazione IRCCS Istituto Nazionale dei Tumori, Milano** · enrollment: 113 (actual)

## Conditions studied

- Post Operative Pain
- Hyperalgesia

## Interventions

- **DRUG:** ketamine infusion
- **DRUG:** Methadone PCA

## Key facts

- **NCT ID:** NCT01594047
- **Lead sponsor:** Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2009-12-01
- **Primary completion:** 2012-06-01
- **Final completion:** 2014-08-01
- **Target enrollment:** 113 (ACTUAL)
- **Last updated:** 2025-10-01


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01594047

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01594047, "Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT01594047. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*