# Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus

> **NCT01643226** · PHASE3 · COMPLETED · sponsor: **Glaukos Corporation** · enrollment: 230 (actual)

## Conditions studied

- Keratoconus

## Interventions

- **DRUG:** riboflavin solution
- **DRUG:** placebo solution
- **DEVICE:** KXL System

## Key facts

- **NCT ID:** NCT01643226
- **Lead sponsor:** Glaukos Corporation
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2012-07
- **Primary completion:** 2015-07
- **Final completion:** 2016-09
- **Target enrollment:** 230 (ACTUAL)
- **Last updated:** 2021-04-26


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01643226

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01643226, "Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus". Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/clinical/NCT01643226. Licensed CC0.

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