# Open-label, Randomized Trial in Participants Undergoing TAVR to Determine Safety & Efficacy of Bivalirudin vs UFH

> **NCT01651780** · PHASE3 · COMPLETED · sponsor: **The Medicines Company** · enrollment: 803 (actual)

## Conditions studied

- Severe Aortic Stenosis
- Transcatheter Aortic Valve Replacement
- Aortic Valve Replacement

## Interventions

- **DRUG:** Bivalirudin
- **DRUG:** Unfractionated Heparin

## Key facts

- **NCT ID:** NCT01651780
- **Lead sponsor:** The Medicines Company
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2012-10
- **Primary completion:** 2015-06
- **Final completion:** 2015-06
- **Target enrollment:** 803 (ACTUAL)
- **Last updated:** 2017-04-07


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01651780

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01651780, "Open-label, Randomized Trial in Participants Undergoing TAVR to Determine Safety & Efficacy of Bivalirudin vs UFH". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT01651780. Licensed CC0.

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