Assess Pharmacokinetics of Fostamatinib in Fed and Fasted State in Combination With Ranitidine to Assess Bioavailability

Conditions

• Pharmacokinetics

Interventions

• DRUG: Fostamatinib - 1 x 150mg mannitol-based 38% drug-loaded tablet(orange reference)
• DRUG: Fostamatinib - 3 x 50mg microcrystalline cellulose-based 13% drug loaded tablets,(blue) fed
• DRUG: Fostamatinib - 1 x 150mg mannitol based 38% drug-loaded tablet (batch variant A)
• DRUG: Fostamatinib - 1 x 150mg mannitol based 38% drug loaded tablet (batch variant B)
• DRUG: Ranitidine

Sponsor

AstraZeneca