Therapy for Pediatric Relapsed or Refractory Precursor B-Cell Acute Lymphoblastic Leukemia and Lymphoma

Conditions

• Recurrent B-Cell Childhood Acute Lymphoblastic Leukemia
• Recurrent Childhood B-Lymphoblastic Lymphoma

Interventions

• DRUG: dexamethasone
• DRUG: vincristine sulfate
• BIOLOGICAL: rituximab
• DRUG: clofarabine
• DRUG: cyclophosphamide
• DRUG: etoposide
• BIOLOGICAL: aldesleukin
• DRUG: pegaspargase
• DRUG: methotrexate
• DRUG: mercaptopurine
• DRUG: cytarabine
• DRUG: mitoxantrone
• DRUG: teniposide
• DRUG: vinblastine
• BIOLOGICAL: natural killer cell infusion
• OTHER: laboratory biomarker analysis
• DRUG: therapeutic hydrocortisone
• PROCEDURE: allogeneic hematopoietic stem cell transplantation
• DEVICE: CliniMACS

Sponsor

St. Jude Children's Research Hospital

Collaborators

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