# Decitabine and Total-Body Irradiation Followed By Donor Bone Marrow Transplant and Cyclophosphamide in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

> **NCT01707004** · PHASE2 · COMPLETED · sponsor: **University of Wisconsin, Madison** · enrollment: 20 (actual)

## Conditions studied

- Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome
- Adult Acute Myeloid Leukemia in Remission
- Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Adult Acute Myeloid Leukemia With Del(5q)
- Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)
- Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
- Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)
- Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)
- de Novo Myelodysplastic Syndromes
- Previously Treated Myelodysplastic Syndromes
- Recurrent Adult Acute Myeloid Leukemia
- Secondary Acute Myeloid Leukemia

## Interventions

- **DRUG:** decitabine
- **DRUG:** fludarabine phosphate
- **DRUG:** busulfan
- **DRUG:** cyclophosphamide
- **DRUG:** tacrolimus
- **DRUG:** mycophenolate mofetil
- **BIOLOGICAL:** filgrastim
- **RADIATION:** total-body irradiation
- **PROCEDURE:** allogeneic bone marrow transplantation
- **OTHER:** laboratory biomarker analysis

## Key facts

- **NCT ID:** NCT01707004
- **Lead sponsor:** University of Wisconsin, Madison
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2013-05-16
- **Primary completion:** 2017-07-22
- **Final completion:** 2017-10-07
- **Target enrollment:** 20 (ACTUAL)
- **Last updated:** 2019-11-21

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01707004

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01707004, "Decitabine and Total-Body Irradiation Followed By Donor Bone Marrow Transplant and Cyclophosphamide in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT01707004. Licensed CC0.

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