Localized High-Risk Soft Tissue Sarcomas Of The Extremities And Trunk Wall In Adults: An Integrating Approach Comprising Standard Vs Histotype-Tailored Neoadjuvant Chemotherapy

PHASE3

Phase

COMPLETED

Status

550

Enrollment

NETWORK

Sponsor class

Conditions

Localized High-risk Soft Tissue Sarcomas of the Extremities and Trunk Wall in Adults

DRUG: epirubicin 60 mg/m2/day (days 1, 2) and ifosfamide 3 g/m2/day (days 1, 2, 3)
DRUG: gemcitabine 900 mg/m2 (days 1 and 8) and docetaxel 75 mg/m2 (day 8)
DRUG: trabectedin 1.3 mg/m2
DRUG: high-dose ifosfamide 14 g/m2, given in in 14 days
DRUG: etoposide 150 mg/m2/day (days 1, 2, 3) and ifosfamide 3g/m2/day (days 1, 2, 3)
DRUG: gemcitabine 1800 mg/m2 (day 1) and dacarbazine 500 mg/m2 (day 1)

Italian Sarcoma Group