# Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001

> **NCT01760005** · PHASE2,PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **Washington University School of Medicine** · enrollment: 490 (estimated)

## Conditions studied

- Alzheimers Disease
- Dementia
- Alzheimers Disease, Familial

## Interventions

- **DRUG:** Gantenerumab
- **DRUG:** Solanezumab
- **DRUG:** Matching Placebo (Gantenerumab)
- **DRUG:** Matching Placebo (Solanezumab)
- **DRUG:** Gantenerumab
- **DRUG:** E2814
- **DRUG:** Lecanemab
- **DRUG:** Matching Placebo (E2814)

## Key facts

- **NCT ID:** NCT01760005
- **Lead sponsor:** Washington University School of Medicine
- **Sponsor class:** OTHER
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2012-12
- **Primary completion:** 2028-04
- **Final completion:** 2028-07
- **Target enrollment:** 490 (ESTIMATED)
- **Last updated:** 2026-02-13

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01760005

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01760005, "Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001". Retrieved via AI Analytics 2026-07-13 from https://api.ai-analytics.org/clinical/NCT01760005. Licensed CC0.

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