Busulfan, Melphalan, and Stem Cell Transplant After Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma

NCT01798004 · clinicaltrials.gov ↗

PHASE1

Phase

COMPLETED

Status

150

Enrollment

NETWORK

Sponsor class

Conditions

Ganglioneuroblastoma
Stage 1 Neuroblastoma
Stage 2 Neuroblastoma
Stage 2A Neuroblastoma
Stage 2B Neuroblastoma
Stage 3 Neuroblastoma
Stage 4 Neuroblastoma
Stage 4S Neuroblastoma

Interventions

PROCEDURE: Autologous Hematopoietic Stem Cell Transplantation
DRUG: Busulfan
DRUG: Cisplatin
DRUG: Cyclophosphamide
DRUG: Doxorubicin Hydrochloride
DRUG: Etoposide
RADIATION: External Beam Radiation Therapy
BIOLOGICAL: Filgrastim
OTHER: Laboratory Biomarker Analysis
DRUG: Melphalan
DRUG: Mesna
PROCEDURE: Peripheral Blood Stem Cell Transplantation
OTHER: Pharmacological Study
DRUG: Topotecan Hydrochloride
DRUG: Vincristine Sulfate

Sponsor

Children's Oncology Group

Collaborators

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