# Donor Natural Killer Cells and Donor Stem Cell Transplant in Treating Patients With High Risk Myeloid Malignancies

> **NCT01823198** · PHASE1,PHASE2 · COMPLETED · sponsor: **M.D. Anderson Cancer Center** · enrollment: 63 (actual)

## Conditions studied

- Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Acute Erythroid Leukemia
- Acute Megakaryoblastic Leukemia
- Acute Myeloid Leukemia
- Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome
- Acute Myeloid Leukemia in Remission
- Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Blasts Under 20 Percent of Bone Marrow Nucleated Cells
- Blasts Under 20 Percent of Peripheral Blood White Cells
- Chronic Myelomonocytic Leukemia
- High Risk Myelodysplastic Syndrome
- Myelodysplastic Syndrome
- Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Therapy-Related Acute Myeloid Leukemia
- Therapy-Related Myelodysplastic Syndrome

## Interventions

- **BIOLOGICAL:** Aldesleukin
- **BIOLOGICAL:** Allogeneic CD56-positive CD3-negative Natural Killer Cells
- **PROCEDURE:** Allogeneic Hematopoietic Stem Cell Transplantation
- **DRUG:** Busulfan
- **DRUG:** Fludarabine Phosphate
- **OTHER:** Laboratory Biomarker Analysis
- **PROCEDURE:** Peripheral Blood Stem Cell Transplantation
- **OTHER:** Pharmacological Study

## Key facts

- **NCT ID:** NCT01823198
- **Lead sponsor:** M.D. Anderson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2013-06-11
- **Primary completion:** 2022-05-10
- **Final completion:** 2022-05-10
- **Target enrollment:** 63 (ACTUAL)
- **Last updated:** 2023-11-07

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01823198

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01823198, "Donor Natural Killer Cells and Donor Stem Cell Transplant in Treating Patients With High Risk Myeloid Malignancies". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT01823198. Licensed CC0.

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