# Brain Muscle Axis During Treatment of Hepatic Encephalopathy With L-ornithine L-aspartate

> **NCT01847651** · PHASE4 · COMPLETED · sponsor: **Imperial College London** · enrollment: 42 (actual)

## Conditions studied

- Hepatic Encephalopathy
- Minimal Hepatic Encephalopathy
- Cirrhosis

## Interventions

- **PROCEDURE:** Vastus Muscle Biopsy
- **DRUG:** LOLA or placebo
- **OTHER:** Cognitive assessment (PHES)
- **OTHER:** Cognitive Assessement (Cogstate)
- **OTHER:** blood and urine sampling
- **OTHER:** Nutritional assessment
- **OTHER:** MRI brain and spectroscopy
- **OTHER:** MRI leg cross section
- **OTHER:** Functional MRI (working memory and attention tasks)

## Key facts

- **NCT ID:** NCT01847651
- **Lead sponsor:** Imperial College London
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2013-08
- **Primary completion:** 2015-06
- **Final completion:** 2015-06
- **Target enrollment:** 42 (ACTUAL)
- **Last updated:** 2015-10-22


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01847651

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01847651, "Brain Muscle Axis During Treatment of Hepatic Encephalopathy With L-ornithine L-aspartate". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT01847651. Licensed CC0.

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