# Cardiac Allograft Remodeling and Effects of Sirolimus

> **NCT01889992** · PHASE1 · TERMINATED · sponsor: **University of Nebraska** · enrollment: 42 (actual)

## Conditions studied

- Cardiac Hypertrophy
- Immunosuppression

## Interventions

- **RADIATION:** Cardiac MRI
- **PROCEDURE:** Coronary angiography with IVUS
- **OTHER:** Cardiac Allograft Remodeling
- **DRUG:** M-TOR Immunosuppression
- **PROCEDURE:** Cardiac Biopsy C4D stain
- **GENETIC:** Genetic Mechanism of M-TOR
- **OTHER:** Cardiopulmonary Exercise Test (CPET)

## Key facts

- **NCT ID:** NCT01889992
- **Lead sponsor:** University of Nebraska
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2013-04-24
- **Primary completion:** 2018-09-27
- **Final completion:** 2018-09-27
- **Target enrollment:** 42 (ACTUAL)
- **Why stopped:** PI left University and project not continued
- **Last updated:** 2023-08-30


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01889992

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01889992, "Cardiac Allograft Remodeling and Effects of Sirolimus". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT01889992. Licensed CC0.

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