# Transoral Surgery Followed By Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer

> **NCT01898494** · PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **ECOG-ACRIN Cancer Research Group** · enrollment: 519 (actual)

## Conditions studied

- Human Papilloma Virus Infection
- Stage III Squamous Cell Carcinoma of the Oropharynx
- Stage IVA Squamous Cell Carcinoma of the Oropharynx
- Stage IVB Squamous Cell Carcinoma of the Oropharynx

## Interventions

- **PROCEDURE:** Transoral surgery
- **RADIATION:** intensity-modulated radiation therapy
- **DRUG:** cisplatin
- **DRUG:** carboplatin

## Key facts

- **NCT ID:** NCT01898494
- **Lead sponsor:** ECOG-ACRIN Cancer Research Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2014-01-22
- **Primary completion:** 2020-11-30
- **Final completion:** 2026-12
- **Target enrollment:** 519 (ACTUAL)
- **Last updated:** 2026-04-01

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01898494

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01898494, "Transoral Surgery Followed By Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT01898494. Licensed CC0.

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