# Inhalational Anesthesia and Precipitation of Dementia: is There a Link?

> **NCT01903421** · NA · UNKNOWN · sponsor: **University Health Network, Toronto** · enrollment: 500 (estimated)

## Conditions studied

- Alzheimer's Disease
- Dementia

## Interventions

- **DRUG:** Spinal anesthesia group: bupivacaine 10-15mg
- **DRUG:** General anesthesia group: induction propofol 1.5-2mg/kg and fentanyl 1-3g/kg, maintained with isoflurane or sevoflurane
- **GENETIC:** Blood test
- **OTHER:** Lumbar spinal tap
- **BEHAVIORAL:** Montreal Cognitive Assessment (MOCA) and MMSE

## Key facts

- **NCT ID:** NCT01903421
- **Lead sponsor:** University Health Network, Toronto
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** UNKNOWN
- **Start date:** 2014-03
- **Primary completion:** 2019-11
- **Final completion:** 2023-07
- **Target enrollment:** 500 (ESTIMATED)
- **Last updated:** 2022-12-05


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01903421

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01903421, "Inhalational Anesthesia and Precipitation of Dementia: is There a Link?". Retrieved via AI Analytics 2026-07-02 from https://api.ai-analytics.org/clinical/NCT01903421. Licensed CC0.

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