# MS-SMART: Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial

> **NCT01910259** · PHASE2 · COMPLETED · sponsor: **University College, London** · enrollment: 445 (actual)

## Conditions studied

- Secondary Progressive Multiple Sclerosis

## Interventions

- **DRUG:** Amiloride
- **DRUG:** Riluzole
- **DRUG:** Fluoxetine
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT01910259
- **Lead sponsor:** University College, London
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2014-12-18
- **Primary completion:** 2018-06-14
- **Final completion:** 2018-07-04
- **Target enrollment:** 445 (ACTUAL)
- **Last updated:** 2020-03-26

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01910259

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01910259, "MS-SMART: Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial". Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/clinical/NCT01910259. Licensed CC0.

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