# Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas

> **NCT01922076** · PHASE1 · COMPLETED · sponsor: **National Cancer Institute (NCI)** · enrollment: 46 (actual)

## Conditions studied

- Anaplastic Astrocytoma
- Anaplastic Oligoastrocytoma
- Diffuse Intrinsic Pontine Glioma
- Diffuse Midline Glioma, H3 K27M-Mutant
- Glioblastoma
- Gliosarcoma

## Interventions

- **DRUG:** Adavosertib
- **OTHER:** Laboratory Biomarker Analysis
- **OTHER:** Pharmacological Study
- **RADIATION:** Radiation Therapy

## Key facts

- **NCT ID:** NCT01922076
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2013-09-03
- **Primary completion:** 2020-12-31
- **Final completion:** 2022-09-30
- **Target enrollment:** 46 (ACTUAL)
- **Last updated:** 2024-01-31


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01922076

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01922076, "Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas". Retrieved via AI Analytics 2026-06-22 from https://api.ai-analytics.org/clinical/NCT01922076. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*