# Prospective, Multicentric, Phase II Randomized Controlled Trial on Two Parallel Groups Comparing the Efficacy of Two Immunosuppressive Drugs (methotrexate, Cyclophosphamide) in Large Granular Lymphocytes Leukemia

> **NCT01976182** · PHASE2 · COMPLETED · sponsor: **Rennes University Hospital** · enrollment: 166 (actual)

## Conditions studied

- Large Granular Lymphocytes Leukemia

## Interventions

- **DRUG:** Methotrexate
- **DRUG:** Cyclophosphamide

## Key facts

- **NCT ID:** NCT01976182
- **Lead sponsor:** Rennes University Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2013-11-26
- **Primary completion:** 2024-02-05
- **Final completion:** 2024-10-07
- **Target enrollment:** 166 (ACTUAL)
- **Last updated:** 2025-01-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT01976182

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT01976182, "Prospective, Multicentric, Phase II Randomized Controlled Trial on Two Parallel Groups Comparing the Efficacy of Two Immunosuppressive Drugs (methotrexate, Cyclophosphamide) in Large Granular Lymphocytes Leukemia". Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/clinical/NCT01976182. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*