# Efficacy Study of Different Laboratory Management Strategies and Drug Regimens in HIV-infected Children in Africa

> **NCT02028676** · PHASE4 · COMPLETED · sponsor: **Medical Research Council** · enrollment: 1206 (actual)

## Conditions studied

- Human Immunodeficiency Virus

## Interventions

- **OTHER:** Clinically Driven Monitoring (CDM)
- **OTHER:** Laboratory plus Clinical Monitoring (LCM)
- **DRUG:** Arm A: ABC+3TC+NNRTI
- **DRUG:** Arm B: ZDV+ABC+3TC+NNRTI->ABC+3TC+NNRTI maintenance
- **DRUG:** Arm C: ZDV+ABC+3TC+NNRTI->ZDV+ABC+3TC maintenance
- **DRUG:** Once-daily ABC+3TC
- **DRUG:** Twice-daily ABC+3TC
- **DRUG:** Continued cotrimoxazole prophylaxis
- **OTHER:** Stopped cotrimoxazole prophylaxis

## Key facts

- **NCT ID:** NCT02028676
- **Lead sponsor:** Medical Research Council
- **Sponsor class:** OTHER_GOV
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2007-03
- **Primary completion:** 2012-03
- **Final completion:** 2012-06
- **Target enrollment:** 1206 (ACTUAL)
- **Last updated:** 2014-06-06

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02028676

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02028676, "Efficacy Study of Different Laboratory Management Strategies and Drug Regimens in HIV-infected Children in Africa". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT02028676. Licensed CC0.

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