# International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma

> **NCT02066220** · PHASE2,PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **Universitätsklinikum Hamburg-Eppendorf** · enrollment: 360 (estimated)

## Conditions studied

- Brain Tumors

## Interventions

- **RADIATION:** Radiotherapy without Carboplatin
- **DRUG:** Reduced-intensity maintenance chemotherapy
- **RADIATION:** Radiotherapy with Carboplatin
- **DRUG:** Maintenance chemotherapy
- **RADIATION:** WNT-HR < 16 years
- **RADIATION:** WNT-HR >= 16 years
- **DRUG:** Induction Chemotherapy
- **RADIATION:** SHH-TP53 M0
- **RADIATION:** SHH-TP53 M+ (germline)
- **RADIATION:** SHH-TP53 (somatic)
- **DRUG:** Vinblastin Maintenance

## Key facts

- **NCT ID:** NCT02066220
- **Lead sponsor:** Universitätsklinikum Hamburg-Eppendorf
- **Sponsor class:** OTHER
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2014-06
- **Primary completion:** 2026-12
- **Final completion:** 2026-12
- **Target enrollment:** 360 (ESTIMATED)
- **Last updated:** 2025-12-04

## Collaborators

- Deutsche Kinderkrebsstiftung

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02066220

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02066220, "International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma". Retrieved via AI Analytics 2026-08-08 from https://api.ai-analytics.org/clinical/NCT02066220. Licensed CC0.

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