# Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma

> **NCT02112916** · PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **National Cancer Institute (NCI)** · enrollment: 847 (actual)

## Conditions studied

- Adult T Acute Lymphoblastic Leukemia
- Ann Arbor Stage II Adult Lymphoblastic Lymphoma
- Ann Arbor Stage II Childhood Lymphoblastic Lymphoma
- Ann Arbor Stage III Adult Lymphoblastic Lymphoma
- Ann Arbor Stage III Childhood Lymphoblastic Lymphoma
- Ann Arbor Stage IV Adult Lymphoblastic Lymphoma
- Ann Arbor Stage IV Childhood Lymphoblastic Lymphoma
- Childhood T Acute Lymphoblastic Leukemia

## Interventions

- **DRUG:** Bortezomib
- **DRUG:** Cyclophosphamide
- **DRUG:** Cytarabine
- **DRUG:** Daunorubicin
- **DRUG:** Daunorubicin Hydrochloride
- **DRUG:** Dexamethasone
- **DRUG:** Doxorubicin
- **DRUG:** Doxorubicin Hydrochloride
- **DRUG:** Etoposide
- **DRUG:** Hydrocortisone Sodium Succinate
- **DRUG:** Ifosfamide
- **DRUG:** Leucovorin Calcium
- **DRUG:** Mercaptopurine
- **DRUG:** Methotrexate
- **DRUG:** Pegaspargase
- **RADIATION:** Radiation Therapy
- **DRUG:** Thioguanine
- **DRUG:** Vincristine
- **DRUG:** Vincristine Sulfate

## Key facts

- **NCT ID:** NCT02112916
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2014-10-04
- **Primary completion:** 2020-03-31
- **Final completion:** 2026-09-16
- **Target enrollment:** 847 (ACTUAL)
- **Last updated:** 2026-05-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02112916

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02112916, "Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma". Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/clinical/NCT02112916. Licensed CC0.

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