Exemestane With or Without Entinostat in Treating Patients With Recurrent Hormone Receptor-Positive Breast Cancer That is Locally Advanced or Metastatic

NCT02115282 · clinicaltrials.gov ↗

PHASE3

Phase

ACTIVE_NOT_RECRUITING

Status

608

Enrollment

NIH

Sponsor class

Conditions

Anatomic Stage III Breast Cancer AJCC v8
Anatomic Stage IV Breast Cancer AJCC v8
Breast Adenocarcinoma
HER2/Neu Negative
Locally Advanced Breast Carcinoma
Metastatic Breast Carcinoma
Recurrent Breast Carcinoma

Interventions

PROCEDURE: Biospecimen Collection
PROCEDURE: Computed Tomography
DRUG: Entinostat
DRUG: Exemestane
DRUG: Goserelin
DRUG: Goserelin Acetate
PROCEDURE: Magnetic Resonance Imaging
OTHER: Placebo Administration
OTHER: Quality-of-Life Assessment

Sponsor

National Cancer Institute (NCI)