# Randomized Trial of Primary Surgery Followed Selective Radiochemotherapy for Rectal Cancer With MRI Negative CRM

> **NCT02121405** · PHASE3 · SUSPENDED · sponsor: **Zhejiang University** · enrollment: 350 (estimated)

## Conditions studied

- Colorectal Neoplasm
- Effects of Radiation Therapy
- Effects of Chemotherapy
- Surgery

## Interventions

- **PROCEDURE:** Rectectomy
- **RADIATION:** Radiotherapy
- **DRUG:** Capecitabine
- **DRUG:** Oxaliplatin

## Key facts

- **NCT ID:** NCT02121405
- **Lead sponsor:** Zhejiang University
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** SUSPENDED
- **Start date:** 2015-10
- **Primary completion:** 2024-02
- **Final completion:** 2026-02
- **Target enrollment:** 350 (ESTIMATED)
- **Why stopped:** DSMB stopped this trial due to the difference of 3-year DFS's rate between two groups more than 5% at the interim analysis in July 2021.
- **Last updated:** 2022-05-11


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02121405

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02121405, "Randomized Trial of Primary Surgery Followed Selective Radiochemotherapy for Rectal Cancer With MRI Negative CRM". Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/clinical/NCT02121405. Licensed CC0.

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