# Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed/Refractory Acute Myeloid Leukemia and Persistent/Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm

> **NCT02159495** · PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **City of Hope Medical Center** · enrollment: 31 (actual)

## Conditions studied

- Adult Acute Myeloid Leukemia in Remission
- Acute Biphenotypic Leukemia
- Early Relapse of Acute Myeloid Leukemia
- Late Relapse of Acute Myeloid Leukemia
- Recurrent Adult Acute Myeloid Leukemia
- Secondary Acute Myeloid Leukemia
- Blastic Plasmacytoid Dendritic Cell Neoplasm
- Acute Myeloid Leukemia
- Adult Acute Lymphoblastic Leukemia
- Interleukin-3 Receptor Subunit Alpha Positive
- Minimal Residual Disease
- Refractory Acute Myeloid Leukemia
- Untreated Adult Acute Myeloid Leukemia

## Interventions

- **DRUG:** cyclophosphamide
- **BIOLOGICAL:** Autologous CD123CAR-CD28-CD3zeta-EGFRt-expressing T Lymphocytes
- **OTHER:** laboratory biomarker analysis
- **BIOLOGICAL:** Allogeneic CD123CAR-CD28-CD3zeta-EGFRt-expressing T-lymphocytes
- **DRUG:** Fludarabine Phosphate

## Key facts

- **NCT ID:** NCT02159495
- **Lead sponsor:** City of Hope Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2015-12-15
- **Primary completion:** 2026-08-06
- **Final completion:** 2026-08-06
- **Target enrollment:** 31 (ACTUAL)
- **Last updated:** 2025-09-16

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02159495

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02159495, "Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed/Refractory Acute Myeloid Leukemia and Persistent/Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT02159495. Licensed CC0.

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