# Combined T Cell Depleted Haploidentical Peripheral Blood Stem Cell and Unrelated Umbilical Cord Blood Transplantation in Patients With Hematologic Malignancies Using a Total Lymphoid Irradiation Based Preparative Regimen

> **NCT02199041** · PHASE2 · TERMINATED · sponsor: **St. Jude Children's Research Hospital** · enrollment: 24 (actual)

## Conditions studied

- Hematological Malignancies

## Interventions

- **DRUG:** Cyclophosphamide
- **DRUG:** Thiotepa
- **DRUG:** Fludarabine
- **DRUG:** Melphalan
- **DRUG:** Mesna
- **BIOLOGICAL:** G-CSF
- **DRUG:** Mycophenolate mofetil
- **DRUG:** Tacrolimus
- **DRUG:** Methylprednisolone
- **RADIATION:** Total lymphoid irradiation
- **BIOLOGICAL:** Lymphocyte infusions
- **DEVICE:** CliniMACS

## Key facts

- **NCT ID:** NCT02199041
- **Lead sponsor:** St. Jude Children's Research Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2014-07-11
- **Primary completion:** 2017-05-23
- **Final completion:** 2017-05-23
- **Target enrollment:** 24 (ACTUAL)
- **Why stopped:** The study was halted early due to slow accrual.
- **Last updated:** 2018-02-07


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02199041

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02199041, "Combined T Cell Depleted Haploidentical Peripheral Blood Stem Cell and Unrelated Umbilical Cord Blood Transplantation in Patients With Hematologic Malignancies Using a Total Lymphoid Irradiation Based Preparative Regimen". Retrieved via AI Analytics 2026-06-14 from https://api.ai-analytics.org/clinical/NCT02199041. Licensed CC0.

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