# Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors in Preventing GVHD

> **NCT02220985** · PHASE2 · COMPLETED · sponsor: **Fred Hutchinson Cancer Center** · enrollment: 84 (actual)

## Conditions studied

- Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Acute Biphenotypic Leukemia
- Acute Leukemia of Ambiguous Lineage
- Acute Undifferentiated Leukemia
- Allogeneic Hematopoietic Stem Cell Transplant Recipient
- Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Blastic Plasmacytoid Dendritic Cell Neoplasm
- Childhood Acute Lymphoblastic Leukemia in Remission
- Childhood Acute Myeloid Leukemia in Remission
- Donor
- Lymphoblastic Lymphoma
- Myelodysplastic Syndrome With Excess Blasts
- Myelodysplastic Syndrome With Excess Blasts-1
- Myelodysplastic Syndrome With Excess Blasts-2
- Recurrent Acute Lymphoblastic Leukemia
- Recurrent Acute Myeloid Leukemia
- Recurrent Childhood Acute Lymphoblastic Leukemia
- Recurrent Childhood Acute Myeloid Leukemia
- Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Refractory Acute Lymphoblastic Leukemia
- Refractory Acute Myeloid Leukemia
- Acute Lymphoblastic Leukemia in Remission
- Acute Myeloid Leukemia in Remission

## Interventions

- **PROCEDURE:** Allogeneic Hematopoietic Stem Cell Transplantation
- **DRUG:** Cyclophosphamide
- **DRUG:** Fludarabine Phosphate
- **OTHER:** Laboratory Biomarker Analysis
- **DRUG:** Methotrexate
- **DRUG:** Mycophenolate Mofetil
- **PROCEDURE:** Peripheral Blood Stem Cell Transplantation
- **PROCEDURE:** Peripheral Blood Stem Cell Transplantation
- **DRUG:** Tacrolimus
- **DRUG:** Thiotepa
- **RADIATION:** Total-Body Irradiation

## Key facts

- **NCT ID:** NCT02220985
- **Lead sponsor:** Fred Hutchinson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2015-02-03
- **Primary completion:** 2025-04-01
- **Final completion:** 2025-05-01
- **Target enrollment:** 84 (ACTUAL)
- **Last updated:** 2025-06-04

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02220985

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02220985, "Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors in Preventing GVHD". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT02220985. Licensed CC0.

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