# Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors

> **NCT02255461** · PHASE1 · TERMINATED · sponsor: **Pediatric Brain Tumor Consortium** · enrollment: 35 (actual)

## Conditions studied

- Childhood Choroid Plexus Tumor
- Childhood Ependymoblastoma
- Childhood Grade III Meningioma
- Childhood High-grade Cerebellar Astrocytoma
- Childhood High-grade Cerebral Astrocytoma
- Childhood Medulloepithelioma
- Recurrent Childhood Anaplastic Astrocytoma
- Recurrent Childhood Anaplastic Oligoastrocytoma
- Recurrent Childhood Anaplastic Oligodendroglioma
- Recurrent Childhood Brain Stem Glioma
- Recurrent Childhood Cerebellar Astrocytoma
- Recurrent Childhood Cerebral Astrocytoma
- Recurrent Childhood Giant Cell Glioblastoma
- Recurrent Childhood Glioblastoma
- Recurrent Childhood Gliomatosis Cerebri
- Recurrent Childhood Gliosarcoma
- Recurrent Childhood Medulloblastoma
- Recurrent Childhood Pineoblastoma
- Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor

## Interventions

- **DRUG:** palbociclib isethionate
- **OTHER:** pharmacological study
- **OTHER:** laboratory biomarker analysis

## Key facts

- **NCT ID:** NCT02255461
- **Lead sponsor:** Pediatric Brain Tumor Consortium
- **Sponsor class:** NETWORK
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2014-12-08
- **Primary completion:** 2019-02-25
- **Final completion:** 2019-02-25
- **Target enrollment:** 35 (ACTUAL)
- **Why stopped:** Data for the primary objectives is complete and the MTD identified in Stratum II.
- **Last updated:** 2021-03-02

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02255461

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02255461, "Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors". Retrieved via AI Analytics 2026-05-30 from https://api.ai-analytics.org/clinical/NCT02255461. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*