Repeat Transplantation for Relapsed or Refractory Hematologic Malignancies Following Prior Transplantation

NCT02259348 · clinicaltrials.gov ↗

PHASE2

Phase

TERMINATED

Status

12

Enrollment

OTHER

Sponsor class

Stopped Investigator's decision.

Conditions

Acute Lymphoblastic Leukemia (ALL)
Acute Myeloid Leukemia (AML)
Myeloid Sarcoma
Chronic Myelogenous Leukemia (CML)
Juvenile Myelomonocytic Leukemia (JMML)
Myelodysplastic Syndrome (MDS)
Non-Hodgkin Lymphoma (NHL)

Interventions

DRUG: Cyclophosphamide
DRUG: Fludarabine
BIOLOGICAL: G-CSF
BIOLOGICAL: Interleukin-2
DRUG: Melphalan
DRUG: Thiotepa
DRUG: Rituximab
BIOLOGICAL: Natural killer cell therapy
BIOLOGICAL: T-cell depleted HPC transplant
BIOLOGICAL: CD45RA-depleted HPC transplant

Sponsor

St. Jude Children's Research Hospital