# Prospective Clinical Trial Evaluating Metronomic Chemotherapy in Patients With High-grade, Operable, Non-metastatic Osteosarcoma of the Extremity

> **NCT02273583** · PHASE2 · UNKNOWN · sponsor: **Grupo de Apoio ao Adolescente e a Crianca com Cancer** · enrollment: 738 (estimated)

## Conditions studied

- High Grade Osteosarcoma

## Interventions

- **DRUG:** continuous oral cyclophosphamide and methotrexate

## Key facts

- **NCT ID:** NCT02273583
- **Lead sponsor:** Grupo de Apoio ao Adolescente e a Crianca com Cancer
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** UNKNOWN
- **Start date:** 2006-05
- **Primary completion:** 2013-06
- **Final completion:** —
- **Target enrollment:** 738 (ESTIMATED)
- **Last updated:** 2016-02-11


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02273583

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02273583, "Prospective Clinical Trial Evaluating Metronomic Chemotherapy in Patients With High-grade, Operable, Non-metastatic Osteosarcoma of the Extremity". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT02273583. Licensed CC0.

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