# Multicenter,Single-arm Study to Evaluate Efficacy, Safety, & Pharmacokinetics of Denosumab in Children w/ OI

> **NCT02352753** · PHASE3 · TERMINATED · sponsor: **Amgen** · enrollment: 153 (actual)

## Conditions studied

- Osteogenesis Imperfecta

## Interventions

- **DRUG:** Denosumab

## Key facts

- **NCT ID:** NCT02352753
- **Lead sponsor:** Amgen
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2015-06-24
- **Primary completion:** 2022-03-26
- **Final completion:** 2022-03-26
- **Target enrollment:** 153 (ACTUAL)
- **Why stopped:** The study was stopped earlier than planned due to safety concerns about high levels of calcium in the blood of the participants
- **Last updated:** 2022-12-28


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02352753

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02352753, "Multicenter,Single-arm Study to Evaluate Efficacy, Safety, & Pharmacokinetics of Denosumab in Children w/ OI". Retrieved via AI Analytics 2026-07-26 from https://api.ai-analytics.org/clinical/NCT02352753. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*