# Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy

> **NCT02432963** · PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **City of Hope Medical Center** · enrollment: 11 (actual)

## Conditions studied

- Adult Solid Neoplasm
- Bladder Carcinoma
- Colon Carcinoma
- Estrogen Receptor Negative
- Head and Neck Squamous Cell Carcinoma
- Hepatocellular Carcinoma
- HER2/Neu Negative
- Melanoma
- Non-Small Cell Lung Carcinoma
- Pancreatic Carcinoma
- Progesterone Receptor Negative
- Rectal Carcinoma
- Renal Cell Carcinoma
- Soft Tissue Sarcoma
- Triple-Negative Breast Carcinoma
- TP53 Gene Mutation
- Unresectable Solid Neoplasm

## Interventions

- **OTHER:** Laboratory Biomarker Analysis
- **BIOLOGICAL:** Modified Vaccinia Virus Ankara Vaccine Expressing p53
- **BIOLOGICAL:** Pembrolizumab

## Key facts

- **NCT ID:** NCT02432963
- **Lead sponsor:** City of Hope Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2016-06-14
- **Primary completion:** 2017-12-04
- **Final completion:** 2026-10-02
- **Target enrollment:** 11 (ACTUAL)
- **Last updated:** 2026-01-28

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02432963

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02432963, "Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy". Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/clinical/NCT02432963. Licensed CC0.

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