# Safety of a Single Administration of AAV2hAQP1, an Adeno-Associated Viral Vector Encoding Human Aquaporin-1 to One Parotid Salivary Gland in People With Irradiation-Induced Parotid Salivary Hypofunction

> **NCT02446249** · PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **MeiraGTx, LLC** · enrollment: 17 (actual)

## Conditions studied

- Squamous Cell Head and Neck Cancer
- Radiation Induced Xerostomia
- Salivary Hypofunction

## Interventions

- **BIOLOGICAL:** AAV2hAQP1

## Key facts

- **NCT ID:** NCT02446249
- **Lead sponsor:** MeiraGTx, LLC
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2015-05-04
- **Primary completion:** 2026-07
- **Final completion:** 2026-07
- **Target enrollment:** 17 (ACTUAL)
- **Last updated:** 2025-09-25

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02446249

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02446249, "Safety of a Single Administration of AAV2hAQP1, an Adeno-Associated Viral Vector Encoding Human Aquaporin-1 to One Parotid Salivary Gland in People With Irradiation-Induced Parotid Salivary Hypofunction". Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/clinical/NCT02446249. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*