# Total Marrow and Lymphoid Irradiation and Chemotherapy Before Donor Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Leukemia

> **NCT02446964** · PHASE1 · COMPLETED · sponsor: **City of Hope Medical Center** · enrollment: 31 (actual)

## Conditions studied

- Adult Acute Lymphoblastic Leukemia in Complete Remission
- Acute Myeloid Leukemia in Remission
- Previously Treated Myelodysplastic Syndrome
- Recurrent Adult Acute Lymphoblastic Leukemia
- Recurrent Adult Acute Myeloid Leukemia
- Recurrent Childhood Acute Lymphoblastic Leukemia
- Recurrent Childhood Acute Myeloid Leukemia
- Childhood Acute Lymphoblastic Leukemia in Complete Remission

## Interventions

- **PROCEDURE:** Bone Marrow Transplantation
- **DRUG:** Cyclophosphamide
- **DRUG:** Fludarabine Phosphate
- **OTHER:** Laboratory Biomarker Analysis
- **DRUG:** Mycophenolate Mofetil
- **PROCEDURE:** Peripheral Blood Stem Cell Transplantation
- **DRUG:** Tacrolimus
- **RADIATION:** Total Marrow Irradiation

## Key facts

- **NCT ID:** NCT02446964
- **Lead sponsor:** City of Hope Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2015-06-25
- **Primary completion:** 2025-05-20
- **Final completion:** 2025-05-20
- **Target enrollment:** 31 (ACTUAL)
- **Last updated:** 2025-06-22

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02446964

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02446964, "Total Marrow and Lymphoid Irradiation and Chemotherapy Before Donor Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Leukemia". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT02446964. Licensed CC0.

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