# Compare Efficacy and Safety of Raltitrexed-based and 5fu-based Neoadjuvant Chemotherapy for Colorectal Liver Metastasis

> **NCT02453490** · PHASE3 · TERMINATED · sponsor: **Zhejiang University** · enrollment: 360 (estimated)

## Conditions studied

- Colorectal Cancer
- Liver Metastasis

## Interventions

- **DRUG:** Raltitrexed-based chemotherapy
- **DRUG:** Raltitrexed-based chemotherapy
- **DRUG:** 5-fluorouracil-based chemotherapy
- **DRUG:** 5-fluorouracil-based chemotherapy

## Key facts

- **NCT ID:** NCT02453490
- **Lead sponsor:** Zhejiang University
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2015-10-11
- **Primary completion:** 2018-09-11
- **Final completion:** 2019-09-11
- **Target enrollment:** 360 (ESTIMATED)
- **Why stopped:** difficultly recruiting
- **Last updated:** 2020-07-14


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02453490

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02453490, "Compare Efficacy and Safety of Raltitrexed-based and 5fu-based Neoadjuvant Chemotherapy for Colorectal Liver Metastasis". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT02453490. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*