# Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers

> **NCT02466971** · PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **National Cancer Institute (NCI)** · enrollment: 450 (actual)

## Conditions studied

- Advanced Vaginal Adenocarcinoma
- Advanced Vaginal Adenosquamous Carcinoma
- Advanced Vaginal Squamous Cell Carcinoma
- Cervical Adenocarcinoma
- Cervical Adenosquamous Carcinoma
- Cervical Squamous Cell Carcinoma
- Stage IB2 Cervical Cancer AJCC v6 and v7
- Stage II Cervical Cancer AJCC v7
- Stage II Vaginal Cancer AJCC v6 and v7
- Stage IIA Cervical Cancer AJCC v7
- Stage IIB Cervical Cancer AJCC v6 and v7
- Stage III Vaginal Cancer AJCC v6 and v7
- Stage IIIB Cervical Cancer AJCC v6 and v7
- Stage IV Vaginal Cancer AJCC v6 and v7
- Stage IVA Cervical Cancer AJCC v6 and v7
- Stage IVA Vaginal Cancer AJCC v6 and v7
- Unresectable Vaginal Carcinoma
- Vaginal Adenocarcinoma
- Vaginal Adenosquamous Carcinoma
- Vaginal Carcinoma
- Vaginal Squamous Cell Carcinoma, Not Otherwise Specified

## Interventions

- **RADIATION:** Brachytherapy
- **DRUG:** Cisplatin
- **RADIATION:** External Beam Radiation Therapy
- **RADIATION:** Intensity-Modulated Radiation Therapy
- **OTHER:** Laboratory Biomarker Analysis
- **RADIATION:** Radiation Therapy
- **DRUG:** Triapine

## Key facts

- **NCT ID:** NCT02466971
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2016-05-10
- **Primary completion:** 2023-01-26
- **Final completion:** 2026-07-14
- **Target enrollment:** 450 (ACTUAL)
- **Last updated:** 2026-04-13

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02466971

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02466971, "Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers". Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/clinical/NCT02466971. Licensed CC0.

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