# Combined Oral Contraceptives and Fluoxetine Versus Combined Oral Contraceptives in Severe Premenstrual Syndrome

> **NCT02488538** · PHASE3 · UNKNOWN · sponsor: **Cairo University** · enrollment: 300 (estimated)

## Conditions studied

- Premenstrual Syndrome

## Interventions

- **DRUG:** Combined oral contraceptives
- **DRUG:** Fluoxetine
- **DRUG:** Combined oral contraceptives placebo
- **DRUG:** Fluoxetine placebo
- **PROCEDURE:** Daily record of severity of problems

## Key facts

- **NCT ID:** NCT02488538
- **Lead sponsor:** Cairo University
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** UNKNOWN
- **Start date:** 2015-07
- **Primary completion:** 2017-07
- **Final completion:** —
- **Target enrollment:** 300 (ESTIMATED)
- **Last updated:** 2017-01-23


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02488538

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02488538, "Combined Oral Contraceptives and Fluoxetine Versus Combined Oral Contraceptives in Severe Premenstrual Syndrome". Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/clinical/NCT02488538. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*