# International Substudy Enigma2 on Postoperative Cognitive Disorders

> **NCT02489097** · PHASE4 · TERMINATED · sponsor: **University Hospital, Geneva** · enrollment: 140 (actual)

## Conditions studied

- Anesthesia
- Delirium, Dementia, Amnestic, Cognitive Disorders

## Interventions

- **DRUG:** Nitrous Oxide
- **OTHER:** Placebo

## Key facts

- **NCT ID:** NCT02489097
- **Lead sponsor:** University Hospital, Geneva
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2013-09
- **Primary completion:** 2016-05
- **Final completion:** 2016-05
- **Target enrollment:** 140 (ACTUAL)
- **Why stopped:** Interim analysis results showed futility
- **Last updated:** 2020-12-16

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02489097

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02489097, "International Substudy Enigma2 on Postoperative Cognitive Disorders". Retrieved via AI Analytics 2026-05-30 from https://api.ai-analytics.org/clinical/NCT02489097. Licensed CC0.

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