# A Study Comparing the Efficacy, Safety and Tolerability of Oral Dydrogesterone 30 mg Daily Versus Crinone 8% Intravaginal Progesterone Gel 90 mg Daily for Luteal Support in In-Vitro Fertilization (LOTUS II)

> **NCT02491437** · PHASE3 · COMPLETED · sponsor: **Abbott** · enrollment: 1034 (actual)

## Conditions studied

- Female Infertility

## Interventions

- **DRUG:** Dydrogesterone 30 mg
- **DRUG:** intravaginal progesterone gel 90 mg

## Key facts

- **NCT ID:** NCT02491437
- **Lead sponsor:** Abbott
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2015-07
- **Primary completion:** 2017-05
- **Final completion:** 2017-05
- **Target enrollment:** 1034 (ACTUAL)
- **Last updated:** 2019-10-01

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02491437

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02491437, "A Study Comparing the Efficacy, Safety and Tolerability of Oral Dydrogesterone 30 mg Daily Versus Crinone 8% Intravaginal Progesterone Gel 90 mg Daily for Luteal Support in In-Vitro Fertilization (LOTUS II)". Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/clinical/NCT02491437. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*