# Gene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different Cannabinoids - a PET Study

> **NCT02492074** · PHASE1 · WITHDRAWN · sponsor: **Central Institute of Mental Health, Mannheim**

## Conditions studied

- Healthy Volunteers
- Modeling Psychosis

## Interventions

- **DRUG:** Delta-9-tetrahydrocannabinol
- **DRUG:** Cannabidiol
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT02492074
- **Lead sponsor:** Central Institute of Mental Health, Mannheim
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** WITHDRAWN
- **Start date:** 2024-12
- **Primary completion:** 2025-04
- **Final completion:** 2025-05
- **Target enrollment:** 0 (ACTUAL)
- **Why stopped:** No documents were ever submitted to the Ethics Committee or the competent authority because it was not possible to establish the planned PET measurements in Germany. Therefore, the study never started.
- **Last updated:** 2025-03-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02492074

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02492074, "Gene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different Cannabinoids - a PET Study". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT02492074. Licensed CC0.

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