# Recombinant EphB4-HSA Fusion Protein With Standard Chemotherapy Regimens in Treating Patients With Advanced or Metastatic Solid Tumors

> **NCT02495896** · PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **University of Southern California** · enrollment: 61 (actual)

## Conditions studied

- Head and Neck Squamous Cell Carcinoma
- Metastatic Pancreatic Adenocarcinoma
- Non-Resectable Cholangiocarcinoma
- Pancreatic Adenocarcinoma
- Recurrent Gallbladder Carcinoma
- Recurrent Non-Small Cell Lung Carcinoma
- Stage III Pancreatic Cancer
- Stage IIIA Gallbladder Cancer
- Stage IIIA Non-Small Cell Lung Cancer
- Stage IIIB Gallbladder Cancer
- Stage IIIB Non-Small Cell Lung Cancer
- Stage IV Gallbladder Cancer
- Stage IV Non-Small Cell Lung Cancer
- Stage IV Pancreatic Cancer
- Unresectable Gallbladder Carcinoma
- Unresectable Pancreatic Cancer

## Interventions

- **DRUG:** Cisplatin
- **DRUG:** Docetaxel
- **DRUG:** Gemcitabine Hydrochloride
- **OTHER:** Laboratory Biomarker Analysis
- **DRUG:** Paclitaxel Albumin-Stabilized Nanoparticle Formulation
- **OTHER:** Pharmacological Study
- **BIOLOGICAL:** Recombinant EphB4-HSA Fusion Protein

## Key facts

- **NCT ID:** NCT02495896
- **Lead sponsor:** University of Southern California
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2015-09-03
- **Primary completion:** 2021-04-01
- **Final completion:** 2026-12-31
- **Target enrollment:** 61 (ACTUAL)
- **Last updated:** 2026-04-29

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02495896

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02495896, "Recombinant EphB4-HSA Fusion Protein With Standard Chemotherapy Regimens in Treating Patients With Advanced or Metastatic Solid Tumors". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT02495896. Licensed CC0.

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