# Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects

> **NCT02506257** · PHASE1 · COMPLETED · sponsor: **SIFI SpA** · enrollment: 90 (actual)

## Conditions studied

- Acanthamoeba Keratitis

## Interventions

- **DRUG:** 0.04% PHMB
- **DRUG:** 0.06% PHMB
- **DRUG:** 0.08% PHMB
- **DRUG:** PHMB Vehicle

## Key facts

- **NCT ID:** NCT02506257
- **Lead sponsor:** SIFI SpA
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2015-11
- **Primary completion:** 2016-04
- **Final completion:** 2016-04
- **Target enrollment:** 90 (ACTUAL)
- **Last updated:** 2017-02-09


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02506257

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02506257, "Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT02506257. Licensed CC0.

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