# Anti-ICOS Monoclonal Antibody MEDI-570 in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma Follicular Variant or Angioimmunoblastic T-cell Lymphoma

> **NCT02520791** · PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **National Cancer Institute (NCI)** · enrollment: 21 (actual)

## Conditions studied

- Advanced Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
- Recurrent Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type
- Recurrent Grade 1 Follicular Lymphoma
- Recurrent Grade 2 Follicular Lymphoma
- Recurrent Grade 3a Follicular Lymphoma
- Recurrent Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma
- Recurrent Mycosis Fungoides
- Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
- Refractory Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type
- Refractory Grade 1 Follicular Lymphoma
- Refractory Grade 2 Follicular Lymphoma
- Refractory Grade 3a Follicular Lymphoma
- Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma
- Stage IB Mycosis Fungoides AJCC v7
- Stage II Mycosis Fungoides AJCC v7
- Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma
- Stage III Mycosis Fungoides AJCC v7
- Stage IV Cutaneous T-Cell Non-Hodgkin Lymphoma
- Stage IV Mycosis Fungoides AJCC v7

## Interventions

- **BIOLOGICAL:** Anti-ICOS Monoclonal Antibody MEDI-570
- **OTHER:** Laboratory Biomarker Analysis
- **OTHER:** Pharmacological Study

## Key facts

- **NCT ID:** NCT02520791
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2016-09-13
- **Primary completion:** 2024-12-18
- **Final completion:** 2026-12-24
- **Target enrollment:** 21 (ACTUAL)
- **Last updated:** 2026-04-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT02520791

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT02520791, "Anti-ICOS Monoclonal Antibody MEDI-570 in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma Follicular Variant or Angioimmunoblastic T-cell Lymphoma". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT02520791. Licensed CC0.

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